Journal of Clinical Case Reports

Sepsis and Propofol Related Infusion Syndrome in a 19-Year-Old Male Patient

Abstract

Sogunro O, Mikesell C and Stausmire J

Propofol Related Infusion Syndrome (PRIS) involves cardiac failure, rhabdomyolysis, metabolic acidosis, and renal failure in critically ill patients receiving long-term propofol infusions at high doses. It carries a high mortality rate of up to 81%. We present a case of a young adult who developed PRIS and survived. A 19-year-old male involved in a motor vehicle collision was intubated and sedated with Propofol. On hospital day 7, the patient suddenly became hypotensive, tachycardic, hyperkalemic, had cardiac arrhythmias, and profound metabolic acidosis. PRIS was suspected and propofol discontinued. The patient was managed expectantly and ultimately discharged on hospital day 22. PRIS is a complex syndrome and requires prompt recognition of its key features including changes in cardiac rhythm, decreased blood pressure, increased oxygenation requirements and derangements in laboratory data. A high clinical suspicion of PRIS should most readily be recognized by the critical care team.