Journal of Clinical Case Reports

Serous Endometrial Intraepithelial Carcinoma Involving Endometrial Polyp Diagnosed by Transcervical Resection: A Case Report

Abstract

Takayuki Ichinose, Shunsuke Nakagawa, Shigenari Namai, Masahiro Shiba, Minako Shimizu, Ranka Kanda, Takeru Sugihara, Masayoshi Morita, Yuko Sasajima, Fukuo Kondo, Hiroshi Uozaki and Takuya Ayabe

Uterine serous carcinoma is a representative histological subtype of endometrial type II cancer. Uterine
serous intraepithelial carcinoma is thought to be a precursor lesion of uterine serous carcinoma. Uterine serous
intraepithelial carcinoma is frequently found to involve an endometrial polyp. Preoperative diagnosis of uterine serous
intraepithelial carcinoma is difficult due to its localized occurrence in the endometrial cavity. We experienced a case
of postmenopausal women with abnormal endometrial cytology. Endometrial biopsy suggested the possibility that
she has a malignant uterine tumor, but it did not reached to the confirmative pathological diagnosis. Hysteroscopy
revealed that she has an endometrial polyp. Pathological analysis of the resected endometrial polyp confirmed that
her disease is uterine serous intraepithelial carcinoma involving endometrial polyp. She underwent hysterectomy,
bilateral salpingo-oophorectomy, omentectomy and retroperitoneal lymphadenectomy. No extrauterine lesion was
detected. Our case suggested the possibility that transcervical resection under the hysteroscope might be useful to
detect serous endometrial intraepithelial carcinoma.