Mamoun Elsayed Shalaby, Hassan M Hassan, Mohammed I Aref and Asmaa D Ebeid
Babkground: Psoriasisis a chronic, inflammatory, T-cell mediated autoimmune disease. Many data demonstrating a significantly increased serum levels of both prolactin and IgE in patients with psoriasis vulgaris and reporting an association between their level and psoriasis severity. Existence of prolactin receptors on epidermal keratinocytes provides more support for the hypothesis that prolactin might have a role in the etiogenesis of psoriasis. Objectives of the study: It was aimed to estimate serum prolactin and immunoglobulin E levels in psoriasis vulgaris before and after NB-UVB therapy. Patients and methods: Fifty patients were submitted in this study. Severity of psoriasis was calculated using PASI score. Results: The results showed the following; a statistically significant difference between patients before and after NB-UVB therapy regarding PASI score (P=0.001), a statistically insignificant difference between patients before and after NB-UVB therapy regarding prolactin level (P=0.06), a statistically significant difference between patients before and after NB-UVB therapy regarding IgE level (P=0.0003), a statistically insignificant correlation between PASI score and prolactin level before NB-UVB therapy (P=0.506), a statistically insignificant correlation between PASI score and prolactin level after NB-UVB therapy (P=0.793), a statistically insignificant correlation between PASI score and IgE level before NB-UVB therapy (P=0.074), and a statistically significant correlation between PASI score and IgE level after NB-UVB therapy (P=0.01). Conclusion: The present study concluded that serum prolactin level is elevated in psoriasis vulgaris but there is no correlation of its level with psoriasis severity. Also, serum IgE level is elevated in psoriasis vulgaris and there is a significant correlation between its levels with psoriasis severity
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