Journal of Clinical Case Reports

Severe Diabetic Ketoacidosis and Acute Pancreatitis Precipitated by Olanzapine in a Nondiabetic Patient

Abstract

Vikash Singh, Pradipta Bhakta, Sabir Saeed and Rajesh Kumar Jain

Olanzapine, a second generation or atypical antipsychotic, is one of the commonly prescribed antipsychotics and has lower incidence of extrapyramidal side effects, sedation and anticholinergic side effects. Atypical antipsychotics like olanzapine are now widely prescribed for treatment of schizophrenia as well as for schizoaffective disorder, bipolar affective disorder, depression and dementia. Olanzapine, has been reported to cause metabolic dysregulation like weight gain, type II diabetes mellitus and hyperlipidemia as compared to conventional antipsychotics. Sometimes patient taking olanzapine may present in acute deterioration like diabetic ketoacidosis complicated with acute pancreatitis. Hereby we are reporting a young patient who presented with life threatening severe diabetic ketoacidosis complicated with acute pancreatitis and acute kidney injury which resolved after withdrawal of olanzapine and with supportive care and Insulin. Combination of diabetic ketoacidosis, acute pancreatitis and acute kidney injury induced by olanzapine is very rarely reported.