International Journal of Neurorehabilitation

Sex Dimorphism in Spinal glial Signaling in Pathological Pain

Abstract

Ya-Yu Zhao, Ying Fei, Hui Chen and Gang Chen

Following painful stimuli and injuries, activated microglia and astrocytes contribute to the facilitation of pain signaling via glia-neuronal signaling pathway. The purpose of this mini-review is to compare recent progress of the last 5 years on microglia and astrocyte control of pain, especially sex differences in pathological pain.