Journal of Clinical & Medical Genomics

Single-cell Genomics: A New Frontier in Cancer Research

Abstract

Bayarak Elesin

Cancer is a highly complex and heterogeneous disease, where the
genetic landscape and cellular makeup of tumors exhibit vast variation not only
between patients but also within a single tumor. This heterogeneity contributes
to challenges in diagnosis, treatment response, and the development of
therapeutic resistance. Traditional bulk genomic sequencing approaches, which
analyze average gene expression or mutation profiles from a large collection of
cells, often fail to capture the diversity of the Tumor Microenvironment (TME) or
reflect the interactions between different cell populations within a tumor.