It is risky to treat any pain with oral medications; acupuncture or topical medications should be used instead. The best and safest way to manage pain, which is felt in the skin, is using topical medications. The pain chemokine cycle makes chronic pain worse in the skin. Pain felt in the skin causes neurogenic inflammation, which spreads inflammation throughout the body. Pain and inflammation are reduced by blocking the pain receptors on skin sensory neurons.
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