Molecular and Genetic Medicine

Source Analysis using Whole Genome Sequencing and Short Tandem Repeats for the Aspergillus Outbreak in an Intensive Care Unit

Abstract

Stephan Kaput*

Aspergillus species, particularly Aspergillus fumigatus, are ubiquitous fungi known for causing infections in immunocompromised individuals. The rising incidences of Aspergillus outbreaks in healthcare settings, especially in Intensive Care Units (ICUs), necessitate the development of advanced diagnostic and analytical techniques to track and control these infections. This article explores the use of Whole Genome Sequencing (WGS) and Short Tandem Repeats (STR) analysis in identifying and understanding the source of an Aspergillus outbreak in an ICU. By integrating these molecular techniques, we provide a comprehensive source analysis, highlighting the advantages and limitations of each method. Our findings underscore the importance of precise genomic tools in outbreak investigations, contributing to improved infection control and patient safety in healthcare environments.