GET THE APP

..

Medicinal Chemistry

ISSN: 2161-0444

Open Access

Stereochemistrical Determination of Dexlansoprazole by Optical Rotation, ECD and 13C-NMR

Abstract

Zhixu Zhou, Linwei Li, Ning Yan, Lei Du, Changshan Sun and Tiemin Sun

Dexlansoprazole is an outstandingproton pump inhibitors, which is a chiral sulfoxide. We firstly report determination of the absolute configuration (AC) of dexlansoprazole by the combination of experimental and calculated optical rotation (OR), electronic circular dichroism (ECD) and 13C-NMR. The high agreement between theoretical and experimental data illustrates that this method would be used to determine the absolute configuration of chiral sulfoxide.

PDF

Share this article

Google Scholar citation report
Citations: 6627

Medicinal Chemistry received 6627 citations as per Google Scholar report

Medicinal Chemistry peer review process verified at publons

Indexed In

 
arrow_upward arrow_upward