Medicinal Chemistry

Structural Elucidation of Cobalt (II) Complexes of 2-Imino-3-(2-hydroxyphenyl)-1-oxozolodin-4-one and Study of its Antimicrobial Relevance

Abstract

Desalegn Demise Sage, Ermias Tamiru and Upadhyay RK

Complex of Co(II) with heterocyclic ligand [2-imino-3-(2-hydroxyphenyl)-1-oxazolodin-4-one] has been synthesized and characterized with the help of elemental analysis, magnetic, 1H-NMR, 13C-NMR, IR and electronic spectral data. IR spectra exhibit the coordination of the ligands to the metal ion through deprotonated phenolic oxygen and heterocyclic nitrogen. All these studies reveal square planar geometry of Co (II) complexes. Synthesized compounds have also been screened against some micro-organisms viz. Escherichia coli, S. aureus, Aspergillus niger and R. bataticola by ‘paper disc’ techn ique. It has been observed that the antimicrobial activities of metal complexes are higher than that of the free ligands.