Journal of AIDS & Clinical Research

Structure-based Design of Protease Inhibitors: Techniques and Applications

Abstract

Juan Francisco

Protease inhibitors are crucial in therapeutic development for various diseases, including viral infections, cancer and neurodegenerative disorders. Structure-based drug design (SBDD) has emerged as a powerful approach in designing protease inhibitors, leveraging detailed knowledge of the enzyme's structure to inform and guide the creation of potent and selective compounds. This article explores the key techniques employed in SBDD of protease inhibitors and highlights their applications in drug discovery and development.