Triveni Bhopal, Jaya Lakshmi Ch, Sai Mallikarjun, Annapurna Sireesha and Srilakshmi
Background: Plasmablastic Lymphoma (PBL) is a rare aggressive subtype of B cell Lymphoma commonly associated with HIV infection. However, PBL is also seen in other immunodeficient and immunocompetent individuals. Because of its rarity and lack of expression of markers used in establishing an initial hematopoietic lineage, it poses a diagnostic challenge to pathologists.
Aim and Objective: To study cases of PBL at a Tertiary Care Oncology Institute, Hyderabad. To summarize the current knowledge on clinical and pathological characteristics, differential diagnosis, therapeutic and prognostic factors.
Observations and Results: Twenty cases of Plasmablastic Lymphoma were studied. Inaddition to Hematoxylin and Eosin staining, Immunohistochemistry was done for further diagnosis. Most of the cases were diagnosed as Poorly differentiated neoplasm on H&E, followed up with IHC, which was positive for CD138 and Ki67.
Conclusion: To increase awareness towards PBL and to avoid misdiagnosis.
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