Journal of Clinical Case Reports

Successful Treatment of Familial Mediterranean Fever with Infliximab in a Colchicine Resistant Patient

Abstract

Makiko Tajika, Mai Arai, Keiko Kobayashi, Koichiro Fujimaki, Kazunaga Agematsu and Yoh Umeda

Familial Mediterranean fever (FMF) is an autosomal recessive disease characterized by recurrent episodes of fever and inflammation. Approximately 10% of patients are reported to be resistant or non-responsive to colchicine. We describe a case of a 30-year-old female patient with familial Mediterranean fever resistant to treatment with colchicine and lack of clinical response to Anakinra, successfully treated with Infliximab. Our case suggests that Infliximab, an anti-TNF antibody, may represent a safe and effective therapy for the treatment of colchicine-resistant FMF.