Medicinal Chemistry

Synthesis and Anticonvulsant Activity of Oxadiazole Derivatives Incorporating Phthalazin-1,4 (2H, 3H)-dione Scaffolds

Abstract

Ehab M. Mostafa, Yomna A. Salem, Ahmed M. Mansour, and Rezk R. Ayyad5*

In this present work, we prepared the 2- (2-mercapto oxadiazole phthalazin (2H, 3H) -1,4-dione (1) and its salt (2) from 2-hydrazino
carbonylmethylphthalazine (2H, 3H) -dione which resulted from condensation of carbondisulfide and potassium hydroxide in ethanol. Also we
prepared 2- (2-mercapto oxadiazole-6,7 –dichloro phthalazin (2H, 3H) -1,4-dione (3) and its salt (4). The two salts (2) and (4) reacted with different
alkylchloroacetates to produce compounds (5 a-f) and (6 a-f) these compounds tested as anticonvulsant drugs, its revealed anticonvulsant activity
compared with phenobarbitone as refrence drug.