Medicinal Chemistry

Synthesis and Anti-inflammatory Study of Novel N-substituted Hydroacridine- 1,8-diones and Bis-hexahydroacridine-1,8-dione Derivatives

Abstract

Omyma A Abd-Allah, Antar A Abdelhamid and Shaaban K Mohamed

We report in this study the synthesis of some new N-substituted hexahydro- acridine-1,8-dione compounds including some new N- 2-hydroxypropylhexahydro- acridine-1,8-diones and their tosylatedoctahydroacridine-1,8-dione derivatives in addition to some bis-hexahydroacridine-1,8-diones via a one pot reaction technique. Moreover, in vivo anti-inflammatory evaluation for some newly synthesized compounds has been investigated. The highly alkylated bishydroacridine- 1,8-dione 5f showed a higher anti- inflammatory potency more than the non-alkylated and the standard employed indomethacin. The structure of all new products has been characterized by IR, 1H-NMR and 13C-NMR.