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Medicinal Chemistry

ISSN: 2161-0444

Open Access

Synthesis and Antimicrobial Activity of Pyrazolyl Triazoles

Abstract

Gaddam Lakshmi Teja, Donthamsetty Venkata Sowmya, Adivireddy Padmaja, Vasikarla Kamala Prasad and Venkatapuram Padmavathi

Pyrazolyl triazoles (5) were prepared by 1,3-dipolar cycloaddition of diazomethane to Schiff base - 3-ethynyl- N-(heteroarylmethylene)aniline (3), followed by oxidation with I2 in DMSO and studied their antimicrobial activity. The pyridine and dichloropyridine substituted compounds 3d, 5c and 5d are potential antibacterial agents against Bacillus subtilis and 3d is a potential antifungal agent against Penicillium chrysogenum.

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