Medicinal Chemistry

Synthesis, Antimicrobial and Antioxidant Activities of Novel series of Cinnamamide Derivatives having Morpholine Moiety

Abstract

Gangadhara Seelolla, Prasad Cheera and Venkateswarlu Ponneri

Structurally morpholine containing Cinnamamide derivatives have been synthesized in quantitative yields by the reaction of different substituted cinnamicacids with morpholine. The structures of the newly synthesized compounds were confirmed by their IR, LC-MS, 1H & 13C-NMR spectral data. The synthesized compounds were evaluated for their antimicrobial activity against bacterial species Bacillus subtilis and Escherichia coli etc and in vitro antioxidant activity by employing DPPH, hydrogen peroxide, and nitric oxide radical scavenging assays. Among these prepared compounds 4i and 4j showed significant antioxidant, antibacterial as well as antifungal activity and these were found to be the most potent activity molecules when compared with that of standard drugs.