Chemical Sciences Journal

Synthesis, Characterization and Antimicrobial Activity of Cu(II), Co(II), Ni(II), Pd(II) and Ru(III) Complexes with Clomiphene Citrate

Abstract

KS Prasad, LS Kumar, HD Revanasiddappa1, B Vijay, B Jayalakshmi

The new mononuclear neutral metal complexes of the type [M(L)2(H2O)nXn] (where n= 0,1,2…; X= Cl; ½ SO4; CH3COO; Br) by using the metal(II/III) salts {M = Cu(II), Co(II), Ni(II), Pd(II) and Ru(III)} with the Clomiphene citrate (L) were synthesized. The ligand and its complexes were characterized by elemental analysis, infrared, ESR, 1H-NMR, electronic spectral studies and magnetic susceptibility measurement, which reveals that L acts as a monodentate ligand. They simultaneously give Thermogravimetric and Differential Thermal Analysis patterns of the complexes recorded at heating rate of 10 °C min-1. The antimicrobial activity of ligand and its metal complexes were evaluated against Gram positive and Gram negative bacteria.