Molecular Biomarkers & Diagnosis

The Free Alpha-Hemoglobin: A Promising Biomarker for β-Thalassemia

Abstract

Uday YH Abdullah, Ahmed GF Al-Attraqchi, Hishamshah M Ibrahim, Zilfalil Bin Alwi, Atif A Baig, Iekhsan Othman, Noraesah B Mahmud, Rosline B Hassan, Nor Hedayah A Bakar and Alawiyah B A Abd Rahman

The purpose is to review the current knowledge and methods of determination of the free alpha hemoglobin with emphasis on its potential implications in patients with beta-thalassemia (β-thal).The severity of β-thal correlates with the extent of imbalance between α- and non-α-globin chains and the amount of the free alpha hemoglobin (free α- Hb) pool in the erythrocytes. To date, there is a lack of biomarkers that convey diagnostic and prognostic values in β-thal. Our ongoing research is aimed to evaluate the potential prognostic and diagnostic implications of free α-Hb to improve the care of patients with β-thal. Our ongoing research is aimed to quantify the free α-Hb for its potential prognostic and diagnosticimplications towards improving the care of patients with various β-thal types in the years to come.