Background: Toxoplasmosis caused by Toxoplasma gondii which is an obligate intracellular parasite with worldwide distribution. The use of nanoparticles is of the methods which have recently been applied in the anti-parasitic studies and have showed the acceptable results.
Objective: The aim of this study was to evaluate the anti-toxoplasma ability of gold nanoparticles in vitro.
Materials and Methods: In this experimental study, the concentrations of 100, 200, 400, 800 and 1000 ppm of gold nanoparticles at different times of 30, 60, 120 and 180 minutes were separately used to evaluate the effect of nanoparticles on the RH strain of tachyzoite of Toxoplasma gondii. The number of live tachyzoites at each concentration as well as at positive and negative controls were determined using microscopy method and trypan blue 1%. The data obtained were analyzed by SPSS 18 software using ANOVA test.
Results: The percentage of live tachyzoites was decreased with increasing of time from 30-180 minutes and increasing of the concentration of gold nanoparticles from 100 to 1000 ppm. The best results were obtained in a concentration of 1000 μg/mL; so that it was able to destroy 100% of tachyzoite in this concentration.
Conclusion: The results showed that gold nanoparticles are able to effectively reduce the tachyzoites of T. gondii and it can be considered as a viable alternative to treat the toxoplasmosis.
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Journal of Antimicrobial Agents received 444 citations as per Google Scholar report
