Journal of Surgery

The Number of 7 Patient’s Clinical Analysis of Duodenal Neuroendocrine Neoplasms

Abstract

Mohammad Abdul Mazid, Gazi Shahinur Akter, Zheng Hui Ye, Xiao-Ping Geng, Fu-Bao Liu,Yi-Jun Zhao, Fan-Huang,Kun Xie,Hong-Chuan Zhao

Aim: The aim of this study was to report and analyze outcomes associated 7 patient’s in-hospital evaluation and investigate of the cliniopathological features diagnosis and treatment of duodenal neuroendocrine neoplasms. So provide knowledge for further understanding of this condition.

Methods: The number of 7 consecutive patients who underwent duodenal (NEN) of the first affiliated hospital of Anhui medical university of December 2012 to 2015 were identified and included for analysis. Demographic and operative data, pathological findings and post-operative outcomes were entered into a computer database. Prognostic factors were analyzed by univariate and multivariate analysis.

Results: The number of 7 patients 3 cases was male and 4 were female; all cases underwent ultrasound and CT examination, 5 cases had endoscopy examination and 1 case had MRI examination. The imaging examinations showed that the tumor was located at descendant duodenum in 2 cases, at duodenal papilla in 1 case and at horizontal duodenum in 1 case. The endoscopy examination showed that the tumor was located at descendant duodenum in 1 case at duodenal papilla in 1 cases and at duodenal bulb in 1 case The 7 patients exhibited dissimilar clinical symptoms. Duodenal NEN was manifested as abdominal pain in 3 cases as jaundice in 2 cases and as headache and fatigue in 2 cases. All patients received surgical treatment, and their diagnoses were confirmed by postoperative pathological and immune histochemical examinations.

Conclusion: Duodenal NEN has low prevalence, insidious onset and usually without specific clinical signs and symptoms. Its diagnosis mainly relies on pathological biopsy and immunohistochemical staining, and surgery is the first option of treatment.