Esat Namal and Refik Bilgin
Objective: Intrahepatic cholangiocarcinoma is the second most frequently encountered primary tumor of the liver after hepatocellular carcinoma. In patients who do not have surgical or other local treatment options, systemic chemotherapy is the standard treatment. However, prognostic factors are not clear for patients with advanced disease who do not have the ability to undergo a surgical operation. In many tumors, there are studies demonstrating the pretreatment effect of positron emission tomography with fluorodeoxyglucose (FDG-PET) metabolic parameters on the prognosis. However, there are a small number of studies that research the effect of FDG-PET metabolic parameters on the prognosis in advanced intrahepatic cholangiocarcinoma. We aimed to investigate the relationship between FDGPET metabolic parameters and survival in advanced intrahepatic cholangiocarcinoma.
Methods: The medical records of 50 advanced intrahepatic cholangiocarcinoma patients from Istanbul Bilim University Medical Oncology Clinic between 2012 and 2018 were reviewed retrospectively. The relationship between patient survival, demographic characteristics and FDG-PET metabolic parameters (SUVmax, metabolic tumor volume, and total lesion glycolysis) was analyzed.
Results: Each unit of increase in metabolic tumor volume increases the risk of death by 1.0057 times, and each unit of increase in total lesion glycolysis increases the risk of death by 1.0034 times. The Cox regression model was found to be significant for metabolic tumor volume and total lesion glycolysis values but not for SUVmax values.
Conclusion: FDG-PET metabolic parameters, such as metabolic tumor volume and total lesion glycolysis, contribute to the prognosis, and routine measurement of these parameters will be beneficial.
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Journal of Oncology Translational Research received 93 citations as per Google Scholar report
