Nuclear Medicine & Radiation Therapy

The Role of Adjuvant Radiation in High Risk Early-Stage Endometrial Cancer

Abstract

Sareena Singh, Amy Armstrong and Analisa DiFeo

Endometrial cancer is the most commonly diagnosed malignancy of the female genital tract in the United States. The role of adjuvant radiation for the treatment of patients with early stage disease is still heavily debated, as no overall survival benefit has been demonstrated in large prospective trials. There is, however, evidence to suggest a decrease in recurrence risk with administration of adjuvant radiotherapy, especially in patients with high-risk features. In this review, we describe the relevant literature to date, define how we determine which patients are considered high or intermediate risk, and describe the findings related to the addition of chemotherapy to adjuvant brachytherapy.