Journal of Bioanalysis & Biomedicine

The Role of Ahr in Anticancer Drug Resistance in Breast Cancer

Abstract

Conghui Zhu and Lili Cui

Breast cancer has been a significant health problem in terms of both morbidity and mortality and has been the second leading cause of cancer deaths worldwide. Exploring and understanding the cellular and molecular mechanisms of BC tumorigenesis and progression as well as resistance to chemotherapeutic drugs involved will be critically important for advancing the overall efficacy of BC therapy. The increasing data demonstrates high levels of constitutively active AhR in mammary tumors, suggesting there is a putative role for the AhR in mammary gland tumorigenesis, while target the AhR for new drug discovery and development has been payed more attention in recent years. The present review aims to provide a relative detailed understanding and progression on the integrated role of AhR in BC tumorigenesis and in BC resistance to chemotherapeutic drugs.