GET THE APP

..

Journal of Genetics and DNA Research

ISSN: 2684-6039

Open Access

Tissue-specific regulation of BMP signaling by Drosophila N-glycanase 1

Abstract

Antonio Galeone

NGLY1 (N-glycanase 1) encodes an evolutionarily conserved enzyme that catalyzes the cleavage of N-glycans from glycoproteins. Mutations in human NGLY1 cause a rare congenital disorder with severe developmental delay, delayed bone age and osteopenia, gastrointestinal dysfunction, small hands/feet and absent tears. However, the mechanism by which NGLY1 deficiency causes the above-mentioned clinical phenotypes is not known, and neither has NGLY1 been linked to any major developmental signaling pathway. Here we show that Drosophila Pngl encodes an Nglycanase and exhibits a high degree of functional conservation with human NGLY1. Loss of Pngl results in developmental midgut defects reminiscent of midgut-specific loss of BMP signaling. Tissuespecific knock-down and rescue exp

Share this article

Google Scholar citation report
Citations: 3

Journal of Genetics and DNA Research received 3 citations as per Google Scholar report

Journal of Genetics and DNA Research peer review process verified at publons

Indexed In

 
arrow_upward arrow_upward