Journal of Clinical Case Reports

Toxic Leucoencephalopathy Due to CHOP Therapy in a Patient with NonHodgkin’s Lymphoma

Abstract

Chetanya Malik, Aditya Kutiyal, Sanjay Pandit, Sandeep Garg and Naresh Gupta

Toxic leucoencephalopathy is damage to cerebral white matter due to exposure to cranial irradiation, environmental toxins, drugs of abuse and chemotherapeutic agents. It results in wide variety of clinical manifestations like personality change, inattention, memory loss, abulia, stupor, coma and death. It leads to white matter demyelination which is visible on T2 weighted MRI as hyperintensity. We report a rare case of a 14-year-old boy with large B cell lymphoma who developed toxic leucoencephalopathy due to exposure to CHOP regimen.