Journal of AIDS & Clinical Research

Transitioning and Sequencing Paediatric Antiretroviral Treatment Regimens in the Dolutegravir Era: Emerging Questions and Considerations

Abstract

Jeffrey M. Samuel, Adrian Gardner, Natella Y. Rakhmanina and Christine Y. Malati*

For patients failing a dolutegravir (DTG)-based regimen, understanding a patient's personal history of antiretroviral (ARV) exposure will become increasingly important. With the universal initiation and switch to DTG-based regimens for currently stable patients, the terminology of first-, second- and third-line antiretroviral therapy (ART) is no longer applicable. The adoption of a patient centric approach will ensure that patients receive the most appropriate regimen to achieve virologic suppression. This article proposes a few recommendations for adopting a patient-centric approach to HIV treatment.