Epitranscriptomics, the study of RNA modifications, has emerged as a promising field in cancer research due to its potential to reveal novel molecular mechanisms underlying tumorigenesis and progression. These RNA modifications, including methylation, pseudouridination, and acetylation, are crucial for regulating RNA stability, splicing, translation, and decay. In cancer, alterations in the epitranscriptome have been linked to various hallmarks of cancer, such as uncontrolled cell proliferation, evasion of apoptosis, and metastasis. Unlike genetic mutations that alter the DNA sequence, epitranscriptomic modifications represent a reversible layer of regulation that can modulate gene expression without changing the genetic code.
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