Depression is a complex and debilitating mental health disorder that affects millions of people worldwide. It is characterized by persistent feelings of sadness, loss of interest or pleasure, changes in appetite and sleep patterns, difficulty concentrating, and a lack of energy. While the exact cause of depression remains elusive, extensive research has been conducted to explore its neurobiological basis. Clinical studies have provided valuable insights into the neurochemical, structural, and functional alterations in the brain associated with depression. This article aims to delve into the understanding of the neurobiological basis of depression by examining key findings from clinical studies. One prominent hypothesis regarding the neurobiological basis of depression focuses on the role of neurotransmitters. Neurotransmitters are chemical messengers that facilitate communication between neurons in the brain. Clinical studies have consistently demonstrated alterations in the levels of certain neurotransmitters in individuals with depression.
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