Rajan Pradhan and Sachin Pradhan
Background: Antihistamine medicines are used in variety of allergic disorders including rhinitis of infectious as well as non-infectious origin. There lacks an extensive study suggesting the increased incidence of Bronchitis on exposure to antihistamine medication. From our experience we noticed increased incidence of Bronchitis in patients using anti allergic medication for rhinitis and this motivated us to undertake a retrospective study on the previous patients’ management data.
Method: We collected and documented the clinical data during last 10 years of approximately 7650 patients treated in our clinic out of which we took 3101 patients for study. Antihistamine medicines Cetrizine and Fexofenadin were used in 2009 patients and these antihistamine medicines were not received by 1092 patients, which were termed as control.
Results: There was significant increase in the incidence of Bronchitis in the patients who were given antihistamine medicines in regular doses in the initial stage of disease.
Conclusion: The patients treated with antihistamines were more prone to develop bronchitis than the control group. There is compelling evidence that antihistamines have this side effect. Additionally, albumin bound structure of Cetrizine that is present in Protein Data Bank suggests that Cetrizine could be circulated in the blood stream to its target through albumin and so it might be possible for it to have distributed to other tissues and so its side reactions. Detailed molecular structural analysis and Ingenuity Pathway Analysis further suggest that cetirizine can bind proteins involved in infectious diseases (such as Bronchitis).
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