Parkinson's disease (PD) is a neurological condition that progresses over time. It happens as a result of dopaminergic neurons dying. Reactive oxygen species and complex I, which affects mitochondrial respiratory function, are two pathophysiological pathways for idiopathic Parkinson's disease. Therefore, using natural antioxidants in PD may offer a different kind of treatment that avoids oxidative stress and slows the evolution of the illness. This review compares and discusses the results of hydroxytyrosol, Ginkgo biloba, Withania somnifera, curcumin, green tea and Hypericum perforatum in PD animal and cell line models. In animal and cell models of PD, the antioxidants under evaluation have been shown to shield brain cells from oxidative damage. However, there is always room for improvement and further research about the therapeutic usefulness of these phytochemicals.
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