Medical Microbiology & Diagnosis

Using Phages to Exterminate Biofilms

Abstract

Manal Mohammed Alkhulaifi

Biofilms are thought to be always a major concern within the healthcare field and food industries. The resistance properties of biofilm mediated bacteria confer persistent that is being somewhat challenging to address. Biofilms can be more resistant to antibiotics than individual planktonic cells. For this reason, the use of novel alternative strategies to management biofilm formation is needed. Currently, phages as an anti-biofilm agent are suggested as possible replacements to antibiotics. In this review, some of diverse strategies to the prevention of biofilm formation have been exhibited by a number of studies. Phages use as anti-biofilm agents can involve either phage application prior to biofilm formation, application to biofilms that are already formed, or using phage impact that is found in association with other additional mechanisms that can physically disrupt the biofilm. The development novel methods as an anti-biofilm agent would hopefully add an important dimension to the search for new potent compounds to solve biofilm-associated infections problems.