Journal of Blood & Lymph

Which Human Leukocyte Antigen (HLA) are Donor-Derived T-cells Restricted to After HLA-Mismatched Hematopoietic Stem Cell Transplantation?

Abstract

Kazuhiro Ikegame*

With advances in preconditioning regimens and supportive care, transplants from related donors who share only one of the two Human Leukocyte Antigen (HLA) haplotypes known as HLA. Haploidentical Hematopoietic Stem Cell Transplantation (haplo-HCT) have been widely performed. Three HLA haplotypes are involved in haplo-HCT: The shared haplotype of the patient and donor (shared HLA), the haplotype uniquely possessed by the donor (donor-specific HLA) and the haplotype belonging to the patient (host-specific HLA). In this context, a critical question arises: Which HLA are donor-derived T cells restricted to after transplantation? Immediately following transplantation, mature donor T and stem cells are transferred to the recipient’s body.