Amid the persistent global challenges posed by the SARS-CoV-2 pandemic, the utilization of rapid antigen tests has significantly enhanced diagnostic capabilities. However, their applicability extends beyond mere diagnosis, offering a promising avenue for whole virus sequencing and variant detection. This article explores the potential and limitations of positive SARS-CoV-2 rapid antigen tests in RNA-based genomic surveillance. By discussing methodologies, challenges, and implications, this research underscores the pivotal role of these tests in preserving comprehensive genomic surveillance amid evolving viral variants.
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