Full Text Content : List of Headings Add Content

Article Name - Relevance to Psoriasis Pathophysiology: The Transcriptional Landscape of Repetitive Elements in Psoriatic Skin from Large Cohort Studies

Heading Content Date Edit Delete
  • Keywords Transcriptional landscape • Psoriasis • Genomics • Pathophysiology ... 2024-02-19
  • Introduction Psoriasis, affecting approximately 2-3% of the global population, is characterized by chronic inflammation and aberrant epidermal proliferation, leading to distinctive scaly plaques on the ski ... 2024-02-19
  • Literature Review Repetitive elements constitute a substantial portion of the human genome and are categorized as either DNA transposons, retrotransposons, or tandem repeats. Traditionally considered "junk ... 2024-02-19
  • Discussion Understanding the role of repetitive elements in psoriasis pathophysiology opens avenues for developing targeted therapeutic interventions. Modulating the expression of repetitive elements, pa ... 2024-02-19
  • Conclusion While challenges persist, the evolving landscape of genomics and its integration with clinical data holds promise for advancing our understanding of psoriasis and translating these insights in ... 2024-02-19
  • Acknowledgement None. ... 2024-02-19
  • Conflict of Interest None. ... 2024-02-19
  • References Thomas, Charles A., Leon Tejwani, Cleber A. Trujillo and Priscilla D. Negraes, et al. "Modeling of TREX1-dependent autoimmune disease using human stem cells highlights L1 accumulation as a ... 2024-02-19