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Article Name - Tumor Resistance Mechanisms in Gastric Cancer Aimed at the Epithelial Cell Adhesion Molecule via Chimeric Antigen Receptor T Cell Therapy

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  • Keywords Gastric cancer • Epithelial cell adhesion molecule • Tumor resistance mechanisms • Genetic alterations ... 2024-02-19
  • Introduction Gastric cancer is a major global health concern, ranking as the fifth most common cancer and the third leading cause of cancer-related deaths worldwide. Despite advances in therapeutic modalit ... 2024-02-19
  • Literature Review Genetic alterations leading to the downregulation of EpCAM expression on gastric cancer cells represent a primary obstacle to the success of CAR T cell therapy. EpCAM, a transmembrane glycopro ... 2024-02-19
  • Discussion Overcoming tumor resistance in gastric cancer may require a multifaceted approach. Combination therapies involving CAR T cells and other immunomodulatory agents, such as immune checkpoint inhi ... 2024-02-19
  • Conclusion In conclusion, the application of Chimeric Antigen Receptor T cell therapy targeting EpCAM in gastric cancer faces formidable challenges related to tumor resistance mechanisms. From genetic al ... 2024-02-19
  • Acknowledgement None. ... 2024-02-19
  • Conflict of Interest None. ... 2024-02-19
  • References Pauken, Kristen E. and E. John Wherry. "Overcoming T cell exhaustion in infection and cancer." Trend Immunol 36 (2015): 265-276. Google Scholar, Crossref, Indexed at Blank, ... 2024-02-19