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Article Name - Dyskerin Downregulation Through AKT-mTOR Signaling Dysregulation Can Cause ER Stress and Encourage Autophagy

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  • Introduction Dyskerin, a vital component of the H/ACA ribonucleoprotein complex, plays a crucial role in the biogenesis of small nucleolar RNAs (snoRNAs) and the maintenance of telomeres. Its functional im ... 2024-07-12
  • Description The interplay between dyskerin, the AKT-mTOR signaling pathway, ER stress, and autophagy is complex and multifaceted. Dyskerin downregulation can influence cellular processes through the dysre ... 2024-07-12
  • Conclusion In metabolic disorders, dysregulation of these pathways can contribute to insulin resistance and metabolic dysfunction. Dyskerin downregulation can impair ribosome biogenesis and telomere main ... 2024-07-12
  • Acknowledgement None. ... 2024-07-12
  • Conflict of Interest None. ... 2024-07-12
  • References Montanaro, Lorenzo, Maurizio Brigotti, J. Clohessy and Stefania Barbieri, et al. "Dyskerin expression influences the level of ribosomal RNA pseudo‐uridylation and telomerase RNA comp ... 2024-07-12