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Article Name - Patients with Lynch-like Syndrome have Pathogenic Germline Variants Found by Whole-Exome Sequencing

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  • Keywords Lynch-like syndrome • Colorectal cancer • Whole-exome sequencing • Pathogenic variants ... 2024-07-12
  • Introduction Lynch Syndrome (LS) is the most common hereditary colorectal cancer syndrome, resulting from germline mutations in DNA mismatch repair (MMR) genes such as MLH1, MSH2, MSH6, and PMS2. However, ... 2024-07-12
  • Literature Review Lynch Syndrome (LS) is a hereditary cancer syndrome caused by pathogenic germline mutations in MMR genes, leading to an increased risk of Colorectal Cancer (CRC) and other malignancies. Diagno ... 2024-07-12
  • Discussion The advent of whole-exome sequencing has revolutionized the genetic diagnosis of hereditary cancer syndromes, including Lynch-like syndrome. By enabling the identification of pathogenic germli ... 2024-07-12
  • Conclusion This study advances our understanding of the genetic basis of Lynchlike syndrome by utilizing whole-exome sequencing to identify pathogenic germline variants in a cohort of LLS patients. The i ... 2024-07-12
  • Acknowledgement None. ... 2024-07-12
  • Conflict of Interest None. ... 2024-07-12
  • References Lynch, Henry T., Carrie L. Snyder, Trudy G. Shaw and Christopher D. Heinen, et al. "Milestones of Lynch syndrome: 1895–2015." Nat Rev Cancer 15 (2015): 181-194. Google Schol ... 2024-07-12