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Article Name - Cyclosporine Nephrotoxicity in Patients with Type 1 Diabetes Mellitus Arbitrary Verdict: A Meta-Analysis of Randomized Control Trials

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  • Keywords Cyclosporine • Renal function • Type 1 diabetes mellitus • Meta-analysis ... 2023-08-03
  • Abbreviations RCT=Randomized Control Trial; CsA=Cyclosporine A; CI=Confidence Intervals; NOS=Newcastle-Ottawa Scale; OR=Odds Ratios; PRISMA=Preferred Reporting Items for Systematic Reviews and Meta-Analyses; OR= ... 2023-08-03
  • Introduction Cyclosporine A (CsA) Short-term treatment improves the rate of clinical remission in recent onset type 1 insulin-dependent diabetes mellitus. It is recognized, however, that the usage of CsA is ... 2023-08-03
  • Materials and Methods We reported this systematic review and meta-analysis according to the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). We also conducted this wor ... 2023-08-03
  • Results Literature search A total of 5823 publications were spotted from the declared databases (1131 in PubMed, 2319 in EMBASE, 512 in web of science and 1539 from the rest of sources). Besides, 322 ... 2023-08-03
  • Discussion This meta-analysis-of seven randomized control trials on CsA for nephrotoxicity risk-do not deny the absence of a degree of harm, however, it demonstrated the absence of a significant harmful ... 2023-08-03
  • Conclusion On 1984 Canadian endocrinologists tried to examine the effect of low-dose, short term CsA for patients, newly diagnosed with type one diabetes mellitus, for remission and restoration of the beta ... 2023-08-03
  • Acknowledgement We would like to thank Asem Ahmad, RN PhD and Nahla Naser MD PhD for their review. ... 2023-08-03
  • Conflict of Interest The authors certify that they have no conflicts of interest to declare including but not limited to financial, consultancy, advisory, institutional and other relationships that might lead to a ... 2023-08-03
  • Authors Contribution AME, AAE, SAA and HHA, contributed in the design, analysis and elucidation of the results and conscripted the manuscript. HHA, SAA steered the preliminary literature search. AAE and AME conducte ... 2023-08-03
  • References Colombo, Maria Delia, Renata Perego and Gilberto Bellia. "Cyclosporine-Associated Nephrotoxicity." Open J Nephrol 3 (2013): 168-169. [Google Scholar] Kahan, BD "Cyclosp ... 2023-08-03