Autoimmune disorders refer to a group of diseases that occur when the immune system attacks healthy cells in the body. These diseases are often characterized by chronic inflammation and can affect different organs and tissues in the body, including the joints, skin and digestive tract. Autoimmune disorders are thought to arise from the interplay between genetic and environmental factors. Recent studies have highlighted the importance of the gut micro biome in modulating immune function and its potential role in the development of autoimmune disorders. This paper explores the interplay between the gut micro biome and genetic factors in autoimmune disorders. The gut micro biome refers to the trillions of microorganisms that reside in the gastrointestinal tract. These microorganisms, which include bacteria, viruses, fungi and parasites, play a critical role in human health by helping to digest food, synthesizing vitamins and modulating immune function. Studies have shown that alterations in the gut microbiome can lead to dysbiosis, a condition characterized by an imbalance in the composition of gut microbial communities.