Psoriasis, affecting approximately 2-3% of the global population, is characterized by chronic inflammation and aberrant epidermal proliferation, leading to distinctive scaly plaques on the skin. While the clinical manifestations of psoriasis are well-documented, the underlying molecular mechanisms driving its pathophysiology remain complex and multifaceted. In recent years, large-scale genomic studies have emerged as powerful tools for unraveling the intricate genomic landscape associated with psoriasis. This article focuses on the significance of repetitive elements in psoriatic skin, examining the transcriptional landscape derived from extensive cohort studies to provide a deeper understanding of psoriasis pathophysiology [1].