The current advances in our understanding of the mechanisms of mycobacteriophage-mediated lysis have provided new insights into how mycobacteriophages break down each layer of the mycobacteria envelope and are important for the development of novel tactics to undermine mycobacteria's ability to survive. A highly effective variety of enzymatic activities could be offered by combining the numerous mycobacteriophage endolysin enzymatic activities, which are designed to destroy specific bonds within the mycobacterial PG. This is a tantalising prospect and merits more research. The application of such enzymes to M, an intracellular pathogen, presents an additional barrier. tuberculosis. Recently, it was shown that an endolysin was active against intracellular bacteria. PlyC, an enzyme from a streptococcal phage, has been demonstrated by the authors to be able to pass through epithelial cell membranes and eradicate intracellular Streptococcus pyogenes. Endolysins become increasingly potential for the destruction of pathogenic bacteria as more investigations on them are conducted. The next challenge will be getting the medication to the infection's source. The distribution of antibiotics and other antimicrobial agents, such as endolysins, which demonstrates to be a potent antimicrobial agent, is being investigated by a number of research organisations.