We emphasized the ongoing situation of biomimetic analogs used in dentistry in this survey. It's clear that intensive research over the years has led to the creation of cutting-edge biomaterials and methods to imitate and replace conventional designs in the craniofacial area. In any case, as a biomimetic concept, it has been observed that materials that are typically determined or naturally close to each other exhibit superior clinical results and greater opportunities for clinical interpretation and patient use. This can be attributed to the diverse concept of organic frameworks, which are constantly changing cycles of mechanical, metabolic, physiochemical, and physiological processes. In order to propel the ebb and flow of research in dentofacial recovery, an interdisciplinary methodology that coordinates medicine, bioengineering, biotechnology, and computational sciences is required. Numerous in vitro and animal model studies demonstrate that original medicines are prepared for groundbreaking clinical treatments. We assume that regenerative medicine has advanced significantly in dentistry; Nonetheless, there are numerous avenues to explore when seeking biomedical examination motivation from a variety of perspectives.