Cyclosporine A (CsA) Short-term treatment improves the rate of clinical remission in recent onset type 1 insulin-dependent diabetes mellitus. It is recognized, however, that the usage of CsA is linked to the associated modification in kidney functions. Erstwhile studies have publicized that nephrotoxicity is not only restricted to patients with kidney transplantation. In almost all studies implemented among patients of kidney or heart transplantations, to the side of patients with autoimmune disorders like rheumatoid arthritis, primary biliary cirrhosis, psoriasis or uveitis, a substantial loss in kidney function was witnessed throughout longterm CsA administration [1]. Our designated researches were accomplished in recent-onset type I diabetic patients to evaluate the alterations in kidney function concomitant with a lowmoderate dose of CsA and to assess its ultimate efficacy to return to normal after termination of this immunosuppressive drug. The first published research assessed the effect of cyclosporine on renal function in diabetic patients was performed in 1985. And the last one was in 2002. Same leader and different teams. However, up till this moment no meta-analyses or systematic reviews were done to establish statistical significance across studies that might otherwise seem to have conflicting results. This will increase the validity and reliability of information and any observed differences. Our drive was to examine the relationship between CsA and the subsequent complications in diabetic patients participating in randomized control trials [2].