Diabetic amyotrophy, also known as diabetic lumbosacral radiculoplexus neuropathy, is a rare but debilitating neurological complication that can affect individuals with non-insulin-dependent diabetes mellitus. While its exact pathogenesis remains elusive, recent research has suggested a possible link between diabetic amyotrophy and inflammatory vasculopathy. Furthermore, a fascinating case study has emerged, presenting an NIDDM patient with painful asymmetric polyradiculopathy and unilateral enhancement of lumbar nerve roots on MRI. This case not only underscores the potential role of immunosuppression in treating diabetic amyotrophy but also highlights the significance of nerve biopsy and gadolinum-enhanced MRI in its diagnostic approach. Diabetic amyotrophy is characterized by subacute-onset nerve damage that predominantly affects the lumbosacral region. Patients with NIDDM are at higher risk of developing this condition, though the exact mechanisms underlying its occurrence are not fully understood. However, recent investigations have revealed compelling evidence pointing towards an inflammatory vasculopathy as a potential contributing factor.