Diabetic Amyotrophy is a relatively rare neurological disorder that primarily affects the motor neurons in the limbs. It is characterized by asymmetric muscle wasting and weakness, with a notable inclination towards upper limb involvement in the majority of cases. This condition has been observed to predominantly affect young males, making it an intriguing area of study for researchers and healthcare professionals alike. Monomelic Amyotrophy, also known as Hirayama disease or juvenile non-progressive amyotrophy, is a clinical syndrome that leads to muscle atrophy and weakness, typically affecting only one limb. The condition was first described by Dr. Keizo Hirayama in 1959 and since then, various research studies have attempted to elucidate its etiology and pathophysiology.