French Guiana experiences significant disparities in life expectancy between males and females. This section presents the current life expectancy statistics for both sexes and highlights the magnitude of the gap. Multiple factors contribute to the sex differences in life expectancy in French Guiana. This section examines the key determinants, including health behaviors, access to healthcare, occupational hazards, and violence, and their impact on male and female life expectancy. The burden of disease, including communicable and non-communicable diseases, varies between sexes in French Guiana. This section discusses the prevalence of major diseases and risk factors and their association with life expectancy disparities [3-5].