DLBCL in PLWH often presents at advanced stages and exhibits unique clinical features compared to DLBCL in the general population. This section highlights the clinical characteristics and subtypes of DLBCL in the context of HIV infection. Accurate diagnosis of DLBCL in PLWH is essential for appropriate management. This section discusses the challenges and considerations in histological diagnosis, immunophenotyping, and molecular profiling. DLBCL in PLWH often presents with unique clinical features, including extra nodal involvement, advanced disease stage, and higher rates of central nervous system (CNS) involvement. This section explores the clinical manifestations and subtypes of DLBCL in the HIV setting.
Effective control of HIV replication with Combination Antiretroviral Therapy (CART) has improved overall survival in PLWH. This section discusses the impact of CART on DLBCL outcomes and the importance of incorporating CART in treatment strategies. DLBCL in PLWH is typically treated with standard chemotherapy regimens. This section explores the role of chemotherapy, as well as the emerging use of immunotherapy, in the management of HIVassociated DLBCL [6].