Micronutrient deficiencies are Prevalent among people living with HIV (PLWH) and can have detrimental effects on their health and disease progression. This article focuses on the prevalence and impact of micronutrient deficiencies among HIV-positive individuals in selected rural districts of South Africa's Eastern Cape Province. It explores the factors contributing to micronutrient deficiencies, the consequences for PLWH, and the potential strategies to address these deficiencies. Understanding and addressing micronutrient deficiencies is crucial for optimizing the health and well-being of HIV-positive individuals in resource-limited settings. Nutrition education and counselling programs can empower PLWH to make informed dietary choices and improve their nutritional status. This section discusses the importance of providing tailored nutrition interventions to address micronutrient deficiencies. Co-occurring infections, such as tuberculosis, and comorbidities, such as chronic diseases, can further exacerbate micronutrient deficiencies among PLWH. This section examines the interplay between these factors and micronutrient status. Micronutrients, including vitamins and minerals, play a critical role in maintaining immune function and overall health. HIV infection and associated factors contribute to an increased risk of micronutrient deficiencies among PLWH. This section introduces the topic and emphasizes the importance of studying micronutrient deficiencies in the context of HIV in rural districts of South Africa's Eastern Cape Province [1,2].