Micronutrient deficiencies among HIV-positive individuals in selected rural districts of South Africa's Eastern Cape Province pose significant challenges to their health and well-being. The complex interplay of socioeconomic factors, co-occurring infections, and limited access to nutritious foods contributes to these deficiencies. By implementing comprehensive strategies that encompass nutrition education, food-based approaches, and collaboration across sectors, healthcare providers and policymakers can improve the nutritional status and overall health outcomes of PLWH in resource-limited settings. Collaboration among healthcare providers, policymakers, and community organizations is essential for implementing effective interventions to address micronutrient deficiencies. Integration of nutrition services within HIV care and treatment programs can help ensure comprehensive care for PLWH. This section emphasizes the importance of collaboration and integration in addressing micronutrient deficiencies. Food insecurity and limited access to nutritious foods are significant challenges faced by individuals living in rural districts of South Africa's Eastern Cape Province. This section discusses the impact of socioeconomic factors on micronutrient deficiencies in this context.